Carrie Anne Fleming, a familiar face to horror TV fans and a steady presence in cult-favorite shows like Supernatural and iZombie, has died at 51 after a private fight with breast cancer.

The Canadian actress passed away on Feb. 26 in Sidney, British Columbia, according to reports. Her Supernatural co-star Jim Beaver confirmed her death, revealing she succumbed to complications tied to the disease.

Fleming may not have been a household name, but for genre fans, she was unforgettable.

Born August 16, 1974, in Digby, Nova Scotia, Fleming built her career the hard way — grinding through smaller roles before carving out a niche in the horror and sci-fi world. She trained in Victoria, British Columbia, studying drama and dance before landing early gigs on shows like Viper and even a brief appearance in Adam Sandler’s Happy Gilmore.

But it was her chilling turn in Masters of Horror that truly put her on the map.

In the infamous 2005 episode “Jenifer,” directed by horror legend Dario Argento, Fleming played a grotesquely disfigured woman with cannibalistic urges — a role that shocked viewers and cemented her reputation as a fearless performer willing to go to dark places.

She later became a fan favorite in Supernatural, playing Karen Singer — the tragic wife of Bobby Singer — in a storyline that left a lasting emotional mark on the long-running CW hit.

Fleming also brought a lighter touch to the screen, appearing in the 2015 TV movie The Unauthorized Full House Story, where she portrayed the mother of Candace Cameron Bure’s character.

In recent years, she enjoyed a steady run on iZombie, appearing across five seasons as Candy Baker, further solidifying her status as a reliable and recognizable TV presence.

Off-screen, Fleming was deeply connected to the stage, performing in productions like Romeo and Juliet, Steel Magnolias, and Fame in British Columbia’s theater scene.

She is survived by her daughter, Madalyn Rose.

A memorial service is expected to be announced in the coming weeks.

Her death marks another quiet loss in Hollywood — one of those working actors whose faces audiences instantly recognize, even if their names don’t always make headlines.

Now, fans are remembering Carrie Anne Fleming for exactly what she was: a fearless character actress who gave everything to every role — even the darkest ones.