The Boys S5 trailer tees up a bloody final season

Prime Video has dropped the full trailer for the fifth and final season of The Boys, teeing up the final confrontation between Antony Starr’s Homelander and Karl Urban’s Butcher—one seeking the original V compound that will make him immortal, the other seeking to commit Supe-genocide with the release of a Supe-specific virus that will kill them all.

As previously reported, things were not looking good for our antiheroes after the S4 finale. They managed to thwart the assassination of newly elected US President Robert Singer, but new Vought CEO/evil supe Sister Sage (Susan Heyward) essentially overthrew the election and installed Senator Steve Calhoun (David Andrews) as president. Calhoun declared martial law, and naturally, Homelander swore loyalty as his chief enforcer. Butcher and Annie (Erin Moriarty) escaped, but the rest of The Boys were rounded up and placed in re-education—er, “Freedom”—camps.

The second season of spinoff series Gen V was set after those events, and the finale concluded with Annie recruiting the main cast members to join the fight against Homelander and the Supes. Season 5 of The Boys picks up where the Gen V finale left off. Per the official premise:

In the fifth and final season, it’s Homelander’s world, completely subject to his erratic, egomaniacal whims. Hughie, Mother’s Milk, and Frenchie are imprisoned in a “Freedom Camp.” Annie struggles to mount a resistance against the overwhelming Supe force. Kimiko is nowhere to be found. But when Butcher reappears, ready and willing to use a virus that will wipe all Supes off the map, he sets in motion a chain of events that will forever change the world and everyone in it. It’s the climax, people. Big stuff’s gonna happen.

Most of the main cast is returning for the final season, and we’ll also see the return of Soldier Boy (Jensen Ackles), aka Homelander’s daddy, revealed in the S4 finale mid-credits scene to be alive and chilling out in cryostorage. In addition, Jared Padalecki will join the cast in an as-yet-undisclosed role. This season will also feature several characters from Gen V: Jordan (London Thor), Marie (Jaz Sinclair), Emma/Little Cricket (Lizze Broadway), Cate (Maddie Phillips), Sam (Asa Germann), and Annabeth (Keeya King).

The first two episodes of The Boys’ fifth and final season premiere on April 8, 2026, on Prime Video, with new episodes airing each week through May 20, 2026.